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Norgine in 2016: continuing


                Key financial figures for 2016                                                                                     to execute Vision 2020



                                                                                                                                   New partnerships in 2016

            Total revenue and income*                                                                                              Building partnerships is key to expanding Norgine’s portfolio, to return to double digit growth and ultimately achieve its Vision

                                                                                                                                   2020 to be the ‘go to’ European specialist pharma partner of choice.
             Year 2016   €368 million                                                                                              What sets Norgine apart from other companies is its flexible and agile approach to partnering and collaboration. Norgine is able

                                                                                                                                   to integrate new products quickly for the benefit of healthcare systems and patients in Europe, Australia and New Zealand.
             Year 2015   €320 million
                                                                                                                                   Norgine has a number of ways of working with partners, whether it’s through in-licensing or acquisition, out-licensing our
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             Year 2014   €298 million                                                                                              products such as MOVICOL , MOVIPREP and PLENVU  to companies in territories where it does not have its own sales
                                                                                                                                   force, joint venture, a profit share or as an investor or conventional licensee.
            *Total revenue and income consist of product sales, partnering                                                         With Norgine’s established infrastructure and extensive history of working in Europe (and Australia and New Zealand), Norgine
            milestones and other income.                                                                                           continued to make significant headway in 2016.

                                                                                                                                   Valeant Pharmaceuticals International, Inc.
            Product sales                                                                                                          (NYSE: VRX and TSX: VRX)

                                                                                                                                   In August 2016, Norgine entered into a licensing agreement with Valeant Pharmaceuticals International, Inc. under
            Down 2% from 2015 due to currency and disposals                                                                        which Valeant has obtained the rights to develop and commercialise PLENVU  Powder for Oral Solution in the US and
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            Underlying growth up by 6.8%* driven by XIFAXAN             Product sales revenue was impacted by
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                                                                        the decline in UK Sterling post the EU                     Canada. PLENVU  is a novel, low-volume (1L) polyethylene glycol-based bowel preparation for cleansing of the colon in
             Year 2016   €295 million                                   referendum, divestment of Norgine’s                        preparation of colonoscopy.
                                                                        South African business in 2015,                            Apharm s.r.l.
             Year 2015   €300 million                                   Norgine’s operations in the Middle East                    In April 2016, Norgine expanded its agreement with Apharm s.r.l. to distribute ZIVEREL  in Austria, Belgium, Denmark,
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                                                                        and North Africa region in 2016 as well
                                                                                                                                   Finland, Germany, Ireland, Luxembourg, the Netherlands, Norway, Sweden, Switzerland and the UK. In June 2015, Norgine
             Year 2014   €284 million                *On a like-for-like basis at   as the disposal of rights to a number of       and Apharm entered into an agreement to distribute ZIVEREL  in Spain, Australia and New Zealand.
                                                     constant exchange rates,
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                                                     underlying revenue growth
                                                     was 6.8%.          non-core products.
                                                                                                                                   Olympus Corporation Of The Americas
                                                                                                                                   In May 2016, Norgine and its subsidiary Arc Medical entered into a distribution agreement for the US and Canada with
            Partnering milestones and other income                                                                                 Olympus Corporation Of The Americas for ENDOCUFF VISION .
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                                                                                                                                   ENDOCUFF VISION  is sold in Europe, Australia and New Zealand through Norgine’s infrastructure.
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            Norgine received net payments of €25.1 million (2015: €4.1 million) related to the achievement of
            milestones by Norgine’s partners. Norgine sold products for €19.5 million (2015: €7.1 million).                        SpePharm Europe B.V.
            2016 Results                                                                                                           In December 2016, Norgine acquired the full ownership of SpePharm Europe B.V. and as of this date this joint venture ceased
                                                                                                                                   and SpePharm Europe B.V. became a subsidiary of Norgine. Through the acquisition of SpePharm, Norgine has acquired the
                                                                                                                                   full rights of DANTRIUM , MUGARD  and LYMPHOSEEK .
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            Norgine has a very strong financial position having repaid €23 million of borrowing in 2016. It has increased
            its net cash position from the prior year by €45 million from €35 million, to €80 million as at December 2016.         Divestment of non-core assets
            Shareholders’ equity has increased from the prior year by €66 million to €195 million as at December 2016.
                                                                                                                                   In 2016, Norgine divested activities to reinforce its strategic focus on Europe in order to deliver profitable growth and create a
                                                                                                                                   dynamic and sustainable business in the long term.
                                                         2015            2016
                                                       €million        €million        Growth                                      In June 2016, Norgine divested its Middle East and North Africa (MENA) operations and product rights to Acino.
                        Total net product revenue         300             295            -2%
                                                                                                                                   Norgine divested the rights of CAMCOLIT  and NORGALAX  for the Netherlands, Belgium and Luxembourg during 2016.
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                        Milestone & other income          20              73             265%
                                                                                                                                   Both products were divested in 2015 for the UK and Ireland.
                                             Total        320             368
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